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DNA repair protein XRCC2; X-ray repair cross-complementing protein 2 (XRCC2)
Function:
- role in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations & deletions
- the BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA & specifically to nicks in duplex DNA
- phosphorylated upon DNA damage, probably by ATM or ATR
- interacts with RAD51D
- part of a BCDX2 complex
- part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 & XRCC3
- in the absence of DNA, XRCC2-RAD51D forms a multimeric ring structure
- in the presence of single-stranded DNA, XRCC2-RAD51D forms a filamentous structure
Structure: belongs to the recA family, RAD51 subfamily
Compartment: nucleus
Related
X-ray repair, complementing defective, repair in Chinese hamster cells-2 (XRCC2) gene
General
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 280 aa
MW = 32 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S247}
Ser phosphorylation site {S249}
References
- UniProt :accession O43543
- NIEHS-SNPs
http://egp.gs.washington.edu/data/xrcc2/
Component-of
BCDX2 complex
Databases & Figures
OMIM 600375
UniProt O43543
Entrez Gene 7516
Kegg hsa:7516
Double strand break repair: homologous recombination