DNA repair protein XRCC1; X-ray repair cross-complementing protein 1 (XRCC1)

Function: - corrects defective DNA strand-break repair & sister chromatid exchange following treatment with ionizing radiation & alkylating agents - phosphorylation of Ser-371 causes dimer dissociation - phosphorylation by CK2 promotes interaction with APTX & APLF - sumoylated - interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) & DNA ligase 3 (LIG3) - interacts with APTX & APLF Structure: - homodimer - contains 2 BRCT domains Compartment: - nucleus - accumulates at sites of DNA damage Polymorphism: - carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- & age-related DNA damage

General

nuclear protein phosphoprotein

Properties

SIZE: entity length = 633 aa MW = 70 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S199} Ser phosphorylation site {S226} Ser phosphorylation site {S241} Thr phosphorylation site {T257} Ser phosphorylation site {S259} Ser phosphorylation site {S266} BRCA1 C-terminal (BRCT) motif SITE: 315-403 MOTIF: Ser phosphorylation site {S371} Ser phosphorylation site {S408} Ser phosphorylation site {S409} Ser phosphorylation site {S410} Ser phosphorylation site {S416} Ser phosphorylation site {S418} Ser phosphorylation site {S421} Ser phosphorylation site {S447} Thr phosphorylation site {T453} Ser phosphorylation site {S485} Thr phosphorylation site {T488} BRCA1 C-terminal (BRCT) motif SITE: 538-629

Databases & Figures

OMIM 194360 UniProt P18887 PFAM correlations Mechanism of base excision repair (v.2)