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DNA repair & recombination protein RAD54-like; RAD54 homolog; hRAD54; hHR54 (RAD54L, RAD54A)
Function:
- role in DNA repair & mitotic recombination
- functions in the recombinational DNA repair (RAD52) pathway
- dissociates RAD51 from nucleoprotein filaments formed on dsDNA
- could be involved in the turnover of RAD51 protein - dsDNA filaments
- may play also an essential role in telomere
- length maintenance & telomere capping in mammalian cells
- interacts with RAD51 through the NH2-terminal domain
Structure:
- belongs to the SNF2/RAD54 helicase family
- contains 1 helicase ATP-binding domain
- contains 1 helicase C-terminal domain
Compartment: nucleus
Expression:
- expression increases approximately 3-fold in late G1 phase compared to other phases of the cell cycle
Pathology:
- defects in RAD54L may be a cause of tumor formation
- alterations are found in a small fraction of primary tumors
a) colon adenocarcinoma
b) non-Hodgkin lymphoma
c) breast ductal carcinoma
Related
X-linked helicase-2; transcriptional regulator ATRX; ATP-dependent helicase ATRX; RAD54 homolog; X-linked nuclear protein XNP (ATRX, ATR2, RAD54L, XH2)
General
DEAD box ATP-dependent helicase
DNA-binding protein
Properties
SIZE: entity length = 747 aa
MW = 84 kD
COMPARTMENT: cell nucleus
MOTIF: helicase
NAME: helicase
SITE: 170-345
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 183-190
peptide motif {296-299}
Helicase C-terminal {500-653}
References
- UniProt :accession Q92698
- NIEHS-SNPs
http://egp.gs.washington.edu/data/rad54l/
Databases & Figures
OMIM 603615
MORBIDMAP 603615
UniProt Q92698
PFAM correlations
Entrez Gene 8438
Kegg hsa:8438
Double strand break repair: homologous recombination