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DNA repair protein RAD52 homolog (RAD52)
Function:
- role in DNA double-stranded break repair
- role in genetic recombination & DNA repair by promoting the annealing of complementary single-stranded DNA & by stimulation of the RAD51 recombinase
- phosphorylated upon DNA damage, probably by ATM or ATR
- forms a undecameric ring
Structure: belongs to the RAD52 family
Compartment: nucleus (putative)
General
DNA-binding protein
Properties
SIZE: entity length = 418 aa
MW = 46 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S2}
Ser phosphorylation site {S199}
Thr phosphorylation site {T318}
Thr phosphorylation site {T335}
References
- UniProt :accession P43351
- NIEHS-SNPs
http://egp.gs.washington.edu/data/rad52/
Databases & Figures
OMIM 600392
UniProt P43351
Pfam PF04098
Entrez Gene 5893
Kegg hsa:5893
Double strand break repair: homologous recombination