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DNA repair
Cellular response to DNA damage, including recognition & repair. Not all DNA damage is recognized & repaired; tolerance to DNA damage is recognized, but poorly understood. Different types of DNA lesions are repaired by different mechanisms.
Classification:
In mammalian systems, 4 types of DNA repair are recognized:
1) DNA mismatch repair
2) DNA excision repair
3) DNA double-strand break repair
4) DNA photoreactivation repair
Pathology:
Human Disorders of DNA Repair include:
1) ataxia telangiectasia
2) Xeroderma pigmentosum
3) trichothiodystrophy
4) hereditary non polyposis colon cancer
5) Li-Fraumeni syndrome
6) Cockayne syndrome
7) Bloom's syndrome
8) Fanconi's anemia
9) early-onset acute myeloid leukemia [2]
Related
DNA damage
Useful
DNA repair (GO:0006281)
Specific
DNA base excision repair
DNA double-strand break repair
DNA mismatch repair; post-replication repair; DNA loop repair
DNA photoreactivation repair
mitochondrial DNA repair
nucleotide excision repair
General
biochemistry
Figures/Diagrams
Figures/diagrams/slides/tables related to DNA repair
DNA Repair
References
- DNA Repair & Mutagenesis, Freidberg et al, ASM Press,
Washington DC, 1995
- O'Neil A
DNA Repair Mutations Lead to AML Predisposition.
In early research, germline mutations shut down a mechanism
that guards against harmful mutations that increase leukemia
risk.
MedPage Today, ASCO Reading Room. Feb 21, 2018
https://www.medpagetoday.com/reading-room/asco/hematologic-malignancies/71284
- Sanders MA, Chew E, Flensburg C et al
Germline loss of MBD4 predisposes to leukaemia due to
a mutagenic cascade driven by 5mC.
bioRxiv preprint first posted online Nov. 1, 2017
https://www.biorxiv.org/content/biorxiv/early/2017/11/01/180588.full.pdf