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DNA polymerase sigma; LAK-1; PAP-associated domain-containing protein 7; terminal uridylyltransferase 5; TUTase 5; Topoisomerase-related function protein 4-1; TRF4-1 (PAPD7, POLS, TRF4)
Function:
- DNA polymerase
- probably involved in DNA repair
- may play a role in sister chromatid cohesion
- does not play a role in replication-dependent histone mRNA degradation
Cofactor: Mg+2 or Mn+2 (putative)
Structure:
- belongs to the DNA polymerase type-B-like family
- contains 1 PAP-associated domain
Compartment: nucleus (probable)
General
DNA polymerase
nuclear protein
Properties
SIZE: entity length = 542 aa
MW = 60 kD
COMPARTMENT: cell nucleus
MOTIF: manganese [Mn]-binding site
SITE: 47-47
manganese [Mn]-binding site
SITE: 49-49
PAP-associated {178-238}
serine-rich region {346-372}
MOTIF: serine residue (SEVERAL)
Database Correlations
OMIM 605198
UniProt Q5XG87
PFAM correlations
Entrez Gene 11044
Kegg hsa:11044
ENZYME 2.7.7.7
References
- UniProt :accession Q5XG87
- NIEHS-SNPs
http://egp.gs.washington.edu/data/pols/