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DNA polymerase mu (POLM)
Function:
- seems to act as an Ig mutase responsible for immunoglobulin (Ig) gene hypermutation
Cofactor: Mg+2 (putative)
Structure:
- belongs to the DNA polymerase type-X family
- contains 1 BRCT domain
Compartment: nucleus (putative)
Expression:
- expressed in a number of tissues
- abundant in thymus
General
DNA polymerase
Properties
SIZE: entity length = 494 aa
MW = 55 kD
COMPARTMENT: cell nucleus
MOTIF: BRCA1 C-terminal (BRCT) motif
SITE: 22-122
DNA-binding motif
SITE: 323-332
MOTIF: Mg+2-binding site
SITE: 330-330
Mg+2-binding site
SITE: 332-332
Mg+2-binding site
SITE: 418-418
Database Correlations
OMIM 606344
UniProt Q9NP87
Pfam PF00533
Kegg hsa:2743
References
UniProt :accession Q9NP87