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DNA polymerase beta (POLB, DNA polymerase X)

Function: - repair polymerase - complexes with DNAase V - may remove primers & fill gaps between Okasaki fragments. - DNA polymerase-beta is the polymerase of base excision repair [2] - has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity Cofactor: binds 2 Mg+2 per subunit (putative) Structure: - monomer - residues 239-252 form a flexible loop which appears to affect the polymerase fidelity (putative) - belongs to the DNA polymerase type-X family Compartment: nucleus

Related

DNA base excision repair

General

DNA polymerase exoribonuclease

Properties

SIZE: MW = 40 kD COMPARTMENT: cell nucleus MOTIF: active site

References

  1. Linn S How many pols does it take to replicate nuclear DNA? Cell 66:185 1991 PMID: 1855251
  2. Sobol et al Nature 379:183 1996
  3. UniProt :accession P06746

Component-of

base excision repair (BER) complex

Databases & Figures

OMIM 174760 UniProt P06746 Kegg hsa:5423 ENZYME 2.7.7.7 Figures/diagrams/slides/tables related to DNA polymerase beta