DNA methyltransferase 1-associated protein 1; DNMAP1; DNMT1-associated protein 1 (DMAP1, KIAA1425)

Function: - role in transcription repression & activation - interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins - can also repress transcription independently of histone deacetylase activity - may specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription - component of the NuA4 histone acetyltransferase complex (HAT complex) - DMAP1 also forms a complex with DNMT1 & HDAC2 - throughout S phase it interacts directly with the N-terminus of DNMT1, which serves to recruit DMAP1 to replication foci - DMAP1 interacts with ING1, - component of the msin3A transcription repressor complex - interacts directly with the transcriptional corepressor TSG101 - interacts with the pro-apoptotic protein DAXX Structure: contains 1 SANT domain Compartment: - nucleus - targeted to replication foci throughout S phase by DNMT1

General

nuclear protein phosphoprotein

Properties

SIZE: entity length = 467 aa MW = 53 kD COMPARTMENT: cell nucleus MOTIF: SANT {149-199} coiled coil {225-275} Thr phosphorylation site {T445} Ser phosphorylation site {S448} serine-rich region {454-460} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S456}

Database Correlations

OMIM 605077 UniProt Q9NPF5 Pfam PF05499 Entrez Gene 55929 Kegg hsa:55929

References

UniProt :accession Q9NPF5