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DNA double strand break
also see DNA double-strand break repair
Pathology:
- aging & Alzheimer disease are associated with an accumulation of neuronal DNA double-strand breaks
- DNA double strand breaks accompany neuronal activity in regions remode chromatin during the process of learning
- repair of the damage by resting may help to consolidate new memories, but as editorialists note
- DNA double-strand repair is not free of errors
- amyloid beta increases neuronal DNA double-strand breaks, possibly by stimulating excessive activity to process information in damaged systems, & may exacerbate errors in DNA repair
Management:
- blocking excitatory amino-acid pathways may facilitate the recuperative effect of resting
Related
DNA double-strand break repair
General
biochemistry
References
- Suberbielle E et al.
Physiologic brain activity causes DNA double-strand breaks in
neurons, with exacerbation by amyloid-bets.
Nat Neurosci 2013 May; 16:613
PMID: 23525040
- Herrup K et al.
Breaking news: Thinking may be bad for DNA.
Nat Neurosci 2013 May; 16:518.
PMID: 23619752