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DNA damage up-regulated protein; DDUP (CTBP1-DT)
Function:
- promotes DNA damage repair through both homologous recombination repair (HRR) & post-replication repair (PRR) mechanisms
- enhances retention of DNA damage response protein RAD18 at sites of DNA damage
- this allows for HRR via association of RAD18 with RAD51C & for PRR via RAD18-mediated promotion of PCNA monoubiquitination
- phosphorylated in an ATR-dependent manner
- phosphorylation is required for interaction with H2AX & RAD18 & for DDUP-mediated DNA damage repair
- interacts with DNA damage response proteins ATR, H2AX, PCNA, RAD18 & RAD51C
- forms a complex with H2AX & RAD18 following DDUP phosphorylation
Compartment:
- nucleus, chromosome
- forms DNA damage-induced foci
Expression: induced by DNA damage
Pharmacology:
- treatment of cells with ATR inhibitor Berzosertib abolishes the interaction of DDUP with H2AX, RAD18 & RAD51C & inhibits formation of DDUP foci, leading to hypersensitivity of cancer cells to DNA-damaging chemotherapeutics
General
nuclear protein
Properties
SIZE: entity length = 186 aa
MW = 20 kD
COMPARTMENT: cell nucleus
Database Correlations
UniProt C0HM98
References
- UniProt :accession C0HM98
- PMID: 35849344