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DNA damage

Damage to DNA in the form of DNA base lesions or apurinic/ apyrimidinic (AP)-sites. These may be repaired by DNA repair mechanisms, or if extensive, the cell may signal the need for apoptosis. DNA damage may induce activity of sodium-hydrogen exchanger (NHE-1), which leads to a rise in intracellular pH deamidation of antiapoptic proteins, including bcl-xL may facilitate apoptosis Assays for different types of DNA damage vary in utility 1) comet assay 2) unscheduled DNA synthesis Tandemly repeated BRCT domains are characteristic of proteins involved in DNA damage signaling. - MDC1

Related

DNA repair

Specific

apurinic/apyrimidinic (AP) site Comet assay (comet tail moment) DNA base lesion

General

biochemistry

References

  1. UniProt :accession Q14676
  2. Zhao R et al. Inhibition of the Bcl-xL deamidation pathway in myeloproliferative disorders. N Engl J Med 2008 Dec 25; 359:2778. PMID: 19109573