DNA cross-link repair 1A protein (hSNM1, hSNM1A, DCLRE1A, KIAA0086, SNM1, SNM1A)

Function: 1) may be required for DNA interstrand cross-link repair 2) required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons 3) binds constitutively to TP53BP1 4) binds CDC27, which is itself a component of the anaphase promoting complex 5) binds PIAS1 Structure: - belongs to the DNA repair metallo-beta-lactamase (DRMBL) family Compartment: - nucleus - in some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1 - found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross-linking agents, these foci overlap with those formed by the MRN complex & BRCA1 Expression: - expressed in brain, heart, kidney, liver, pancreas, placenta, skeletal muscle - induced during mitosis mRNA encoding this protein contains an internal ribosome entry site (IRES) in its 5'-UTR that generally suppresses translation while specifically promoting expression during mitosis, when cap-dependent translation may be impaired

General

nuclear protein phosphoprotein

Properties

SIZE: MW = 116 kD entity length = 1040 aa COMPARTMENT: cell nucleus MOTIF: nuclear localization {1-190} nuclear focus formation {396-614} MOTIF: Ser phosphorylation site {S590}

Database Correlations

UniProt Q6PJP8 Pfam PF07522

References

UniProt :accession Q6PJP8