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nucleobindin-2; DNA-binding protein NEFA; gastric cancer antigen Zg4 (NUCB2 NEFA)
Function:
- Ca+2-binding protein
- may have a role in Ca+2 homeostasis
Structure:
- belongs to the nucleobindin family
- contains 2 EF-hand domains
Compartment:
- membrane; peripheral membrane protein
- cytoplasm
- secreted
Alternative splicing: named isoforms=2
Expression:
- predominantly expressed in spleen, testis & normal stomach
Polymorphism: deletion of Gln-402 is frequent
Notes:
- NEFA stands for N=DNA-binding; EF=EF-hand; A=acidic region
General
Ca+2 binding protein
DNA-binding protein
Properties
SIZE: entity length = 420 aa
MW = 50 kD
COMPARTMENT: cytoplasm
MOTIF: signal sequence {1-24}
DNA-binding motif
SITE: 171-223
Binds to necdin {213-420}
MOTIF: EF hand
SITE: 241-276
Ca+2-binding site
SITE: 254-265
acidic region {282-293}
MOTIF: acidic residue (SEVERAL)
EF hand
SITE: 293-328
Ca+2-binding site
SITE: 306-317
Database Correlations
OMIM 608020
UniProt P80303
Entrez Gene 4925
Kegg hsa:4925
References
UniProt :accession P80303