polycomb group RING finger protein 2; DNA-binding protein mel-18; RING finger protein 110; zinc finger protein 144 (PCGF2, MEL18, RNF110, ZNF144)

Function: - transcriptional repressor - binds specifically to the DNA sequence 5'-GACTNGACT-3' - has tumor suppressor activity - may play a role in control of cell proliferation &/or neural cell development - regulates proliferation of early T progenitor cells by maintaining expression of HES1 - role in antero-posterior specification of the axial skeleton - negative regulation of the self-renewal activity of hematopoietic stem cells - component of the polycomb group (PcG) multiprotein PRC1 complex - phosphorylated - unphosphorylated protein forms homodimers (putative) Structure: contains 1 RING-type Zn+2 finger Compartment: nucleus Expression: - detected in all tissues examined - high expression in placenta lung & kidney - low expression in liver, pancreas & skeletal muscle

General

DNA-binding protein ring finger protein transcriptional silencer (transcriptional repressor)

Properties

SIZE: entity length = 344 aa MW = 38 kD COMPARTMENT: cell nucleus MOTIF: RING-finger {18-57} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif nuclear translocation signal {81-95} serine-rich region {242-344} MOTIF: serine residue (SEVERAL)

Database Correlations

OMIM 600346 UniProt P35227 Pfam PF00097 Kegg hsa:7703

References

UniProt :accession P35227