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DNA-binding protein inhibitor ID-4; inhibitor of DNA binding 4 (ID4)
Function:
- ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding
- heterodimer with other HLH proteins
Structure: contains 1 basic helix-loop-helix (bHLH) domain
Compartment: nucleus
General
DNA-binding protein inhibitor; inhibitor of DNA binding (ID)
Properties
SIZE: entity length = 161 aa
MW = 17 kD
COMPARTMENT: cell nucleus
MOTIF: alanine-rich region {39-48}
MOTIF: alanine residue (SEVERAL)
helix-loop-helix
NAME: helix-loop-helix
SITE: 65-105
FOR-BINDING-VIA: helix-loop-helix
proline-rich region
SITE: 118-124
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 600581
UniProt P47928
Pfam PF00010
Entrez Gene 3400
Kegg hsa:3400
References
- UniProt :accession P47928
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/ID4ID40916ch6p22.html