DNA-binding protein inhibitor ID-3; inhibitor of DNA binding 3; ID-like protein inhibitor HLH 1R21; Helix-loop-helix protein HEIR-1 (ID3, 1R21, HEIR-1)

Function: - ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding - ID-3 inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer - may inhibit other transcription factors - interacts with COPS5 & COPS7A (putative) - homodimer, & heterodimer with other HLH proteins Structure: contains 1 basic helix-loop-helix (bHLH) domain Compartment: nucleus Expression: - expressed abundantly in lung, kidney & adrenal gland, but not in adult brain - induced by phorbol 12-myristate 13-acetate (PMA)

Properties

SIZE: entity length = 119 aa MW = 13 kD COMPARTMENT: cell nucleus MOTIF: helix-loop-helix NAME: helix-loop-helix SITE: 41-81 FOR-BINDING-VIA: helix-loop-helix

Database Correlations

OMIM 600277 UniProt Q02535 Pfam PF00010 Entrez Gene 3399 Kegg hsa:3399

References

UniProt :accession Q02535