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DNA-binding protein inhibitor ID-2; inhibitor of DNA binding 2 (ID2)
Function:
- ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding
- ID2 may be an inhibitor of tissue-specific gene expression
- heterodimer with other HLH proteins
Structure: contains 1 basic helix-loop-helix (bHLH) domain
Compartment: nucleus
Expression:
- highly expressed in early fetal tissues, including those of the central nervous system
- found in most early fetal tissues but not in the corresponding mature tissues
General
DNA-binding protein inhibitor; inhibitor of DNA binding (ID)
Properties
SIZE: entity length = 134 aa
MW = 15 kD
COMPARTMENT: cell nucleus
MOTIF: helix-loop-helix
NAME: helix-loop-helix
SITE: 36-76
FOR-BINDING-VIA: helix-loop-helix
Database Correlations
OMIM 600386
UniProt Q02363
Pfam PF00010
Entrez Gene 3398
Kegg hsa:3398
References
UniProt :accession Q02363