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DNA-binding protein inhibitor ID-1; inhibitor of DNA binding 1 (ID1)
Function:
- ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding
- heterodimer with other HLH proteins
- interacts with COPS5
Structure: contains 1 basic helix-loop-helix (bHLH) domain
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression:
- expression correlates with proliferation in some types of cells
General
DNA-binding protein inhibitor; inhibitor of DNA binding (ID)
Properties
SIZE: entity length = 155 aa
MW = 16 kD
COMPARTMENT: cell nucleus
MOTIF: helix-loop-helix
NAME: helix-loop-helix
SITE: 66-106
FOR-BINDING-VIA: helix-loop-helix
Database Correlations
OMIM 600349
UniProt P41134
Pfam PF00010
Entrez Gene 3397
Kegg hsa:3397
References
UniProt :accession P41134