DNA-binding protein A; Y-box-binding protein 3; cold shock domain-containing protein A; single-strand DNA-binding protein NF-GMB (YBX3 CSDA DBPA)

Function: - binds to the GM-CSF promoter - seems to act as a gene repressor - binds also to full length mRNA & to short RNA sequences containing the consensus site 5'-UCCAUCA-3' - may have a role in translation repression - found in a mRNP complex with YBX2 (putative) Structure: contains 1 CSD domain (cold-shock) Compartment: cytoplasm. nucleus Alternative splicing: - named isoforms=3; - additional isoforms seem to exist Expression: highly expressed in skeletal muscle & heart

General

DNA-binding protein phosphoprotein

Properties

SIZE: entity length = 372 aa MW = 40 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl cold shock NAME: cold shock SITE: 93-157 MOTIF: Ser phosphorylation site {S134} Ser phosphorylation site {S201} Ser phosphorylation site {S203} Ser phosphorylation site {S204} Ser phosphorylation site {S324}

Database Correlations

OMIM 603437 UniProt P16989 Pfam PF00313 Entrez Gene 8531 Kegg hsa:8531

References

UniProt :accession P16989