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DNAzyme Dz13 (c-Jun DNAzyme)
Mechanism of action:
- single strands of DNA that specifially bind to & degrade c-Jun messenger RNA
- when injected into nodular basal cell carcinoma, results in
a) tumor cell apoptosis,
b) inhibition of angiogenesis
c) stimulation of adaptive immune responses
- increases the proapoptotic molecules caspase 3, caspase 8, caspase 9 & p53 in tumors
- decreases in the antiapoptotic protein Bcl-2 in tumors
- increases density of immune & inflammatory infiltrate in & around the tumor
General
DNAzyme
References
- Cho E-A et al.
Safety and tolerability of an intratumorally injected
DNAzyme, Dz13, in patients with nodular basal-cell carcinoma:
A phase 1 first-in-human trial (DISCOVER).
Lancet 2013 May 25; 381:1835
PMID: 23660123
- Grassi G and Grassi M.
First-in-human trial of Dz13 for nodular basal-cell carcinoma.
Lancet 2013 May 25; 381:1797.
PMID: 23660122