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DNAzyme
Mechanism of action:
- single strands of DNA that bind & degrade messenger RNA
Specific
DNAzyme Dz13 (c-Jun DNAzyme)
General
pharmaceutical agent
single-strand DNA (ss DNA)
References
- Cho E-A et al.
Safety and tolerability of an intratumorally injected
DNAzyme, Dz13, in patients with nodular basal-cell carcinoma:
A phase 1 first-in-human trial (DISCOVER).
Lancet 2013 May 25; 381:1835
PMID: 23660123
- Grassi G and Grassi M.
First-in-human trial of Dz13 for nodular basal-cell carcinoma.
Lancet 2013 May 25; 381:1797.
PMID: 23660122