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DnaJ homolog subfamily C member 10 (ER-resident protein ERdj5, macrothioredoxin, MTHr, DNAJC10, ERDJ5, UNQ495/PRO1012)
Function:
1) endoplasmic reticulum co-chaperone may play a role in protein folding & translocation across the endoplasmic reticulum membrane
2) may act as a co-chaperone for HSPA5
3) interacts with HSPA5 via its J domain
Compartment: secreted, endoplasmic reticulum lumen
Alternative splicing: named isoforms=2
Expression: induced during ER stress
Structure:
- contains 1 J domain
- contains 4 thioredoxin domains
General
DNAJ homolog subfamily C
glycoprotein
secreted protein
Properties
SIZE: MW = 91 kD
entity length = 793 aa
COMPARTMENT: endoplasmic reticulum
MOTIF: signal sequence {1-32}
J domain {35-100}
thioredoxin domain
SITE: 130-232
MOTIF: cysteine residue {X1}
MODIFICATION: cysteine residue {X2}
cysteine residue {X2}
MODIFICATION: cysteine residue {X1}
thioredoxin domain
SITE: 454-553
MOTIF: cysteine residue {X1}
MODIFICATION: cysteine residue {X2}
cysteine residue {X2}
MODIFICATION: cysteine residue {X1}
N-glycosylation site {N530}
thioredoxin domain
SITE: 557-662
MOTIF: cysteine residue {X1}
MODIFICATION: cysteine residue {X2}
cysteine residue {X2}
MODIFICATION: cysteine residue {X1}
thioredoxin domain
SITE: 671-778
MOTIF: cysteine residue {X1}
MODIFICATION: cysteine residue {X2}
cysteine residue {X2}
MODIFICATION: cysteine residue {X1}
ER retention {790-793}
Database Correlations
OMIM 607987
UniProt Q8IXB1
PFAM correlations
References
UniProt :accession Q8IXB1