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drosophila discs large [dlg] protein
Mutations in dlg (discs large gene) lead to a loss of tight (septate) junctions between epithelial cells & aberrant proliferation of cells in the imaginal disk. Human homolog is SAP97.
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discs large homolog
drosophila discs large [dlg] gene
General
anti-oncoprotein (tumor suppressor protein)
cytoskeletal protein
guanylate kinase
invertebrate-specific protein
Properties
COMPARTMENT: cytoplasm
CELL: unspecified cell type
ORGANISM: Drosophila
MOTIF: kinase domain
SITE: N-TERMINAL
MOTIF: binding site
FOR-BINDING-OF: guanosine monophosphate
MOTIF: arginine residue (2)
tyrosine residue
consensus repeat {N-TERMINAL}
src homology 3 [SH3] domain
SITE: CENTRAL
kinase domain
MOTIF: ATP-binding site
NAME: ATP-binding site
kinase domain
SITE: C-TERMINAL
MOTIF: binding site
FOR-BINDING-OF: guanosine monophosphate
MOTIF: arginine residue (2)
tyrosine residue
References
- Pawson T
Protein modules and signalling networks
Nature 373:573 1995
PMID: 7531822