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DJ-1-binding protein; CAP-binding protein complex-interacting protein 1 (DJBP, EFCAB6, KIAA1672)
Function:
- inhibits androgen receptor by recruiting histone deacetylase complex; protein DJ-1 antagonizes this inhibition by disrupting complex
- binds PARK7
- part of a ternary complex containing PARK7, DJBP & AR
Structure: contains 17 EF-hand domains
Compartment: nucleus
Alternative splicing: named isoforms=5
Expression: secifically expressed in the testis
General
Ca+2 binding protein
nuclear protein
Properties
SIZE: MW = 173 kD
entity length = 1501 aa
COMPARTMENT: cell nucleus
MOTIF: EF hand
SITE: 70-105
EF hand
SITE: 172-207
EF hand
SITE: 297-332
EF hand
SITE: 403-438
EF hand
SITE: 439-474
EF hand
SITE: 504-539
EF hand
SITE: 634-669
EF hand
SITE: 741-776
EF hand
SITE: 847-882
EF hand
SITE: 883-918
EF hand
SITE: 964-999
EF hand
SITE: 1069-1104
EF hand
SITE: 1176-1211
EF hand
SITE: 1212-1247
PARK7 interaction {1303-1501}
MOTIF: EF hand
SITE: 1359-1394
AR interaction {1407-1501}
EF hand
SITE: 1434-1469
EF hand
SITE: 1470-1501
Database Correlations
UniProt Q5THR3
Pfam PF00036
References
UniProt :accession Q5THR3