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di-N-acetylchitobiase (CTBS, CTB)
Function:
- role in the degradation of asparagine-linked glycoproteins
- hydrolyzes N-acetyl-beta-D-glucosamine (1-4)N-acetyl- glucosamine chitobiose core from the reducing end of the bond
- requires prior cleavage by glycosylasparaginase
Structure: belongs to the glycosyl hydrolase 18 family
Compartment: lysosome
General
glycoprotein
hydrolase
Properties
SIZE: entity length = 385 aa
MW = 44 kD
COMPARTMENT: lysosome
MOTIF: signal sequence {1-38}
glutamate residue {E143}
N-glycosylation site {N193}
N-glycosylation site {N228}
N-glycosylation site {N262}
N-glycosylation site {N299}
Database Correlations
OMIM 600873
UniProt Q01459
Pfam PF00704
Kegg hsa:1486
References
UniProt :accession Q01459