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disks large homolog 5; discs large protein P-dlg; placenta & prostate DLG (DLG5, KIAA0583, PDLG)
Function:
1) plasma membrane, maintenance of epithelial cells
2) transmission of extracellular signals to membrane & cytoskeleton
3) interacts with MPP1
4) interacts with CTNNB1 & SORBS3 (3rd domain) to form a ternary complex
Structure:
- belongs to the MAGUK family
- contains 1 guanylate kinase-like domain
- contains 4 PDZ domain (DHR domain)s
- contains 1 SH3 domain
Compartment:
- plasma membrane
- cell-cell junction, sites of cell-cell contact
Alternative splicing: named isoforms=5
Expression:
- expressed in the placenta, prostate > thyroid, spinal cord, trachea, adrenal gland, skeletal muscle, pancreas, heart, brain, liver, kidney
- a short splice product shows more limited expression, being absent from at least the brain
Related
discs large homolog
disks large-associated protein 1; DAP-1; guanylate kinase-associated protein; hGKAP; SAP90/PSD-95-associated protein 1; SAPAP1; PSD-95/SAP90-binding protein 1 (DLGAP1 DAP1 GKAP)
drosophila discs large [dlg] protein
General
cytoskeletal protein
phosphoprotein
Properties
SIZE: entity length = 1919 aa
MW = 214 kD
COMPARTMENT: cytoplasm
MOTIF: serine-rich region {113-123}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S132}
PDZ domain
NAME: PDZ domain
SITE: 620-710
PDZ domain
NAME: PDZ domain
SITE: 705-796
proline-rich region
SITE: 982-1066
MOTIF: proline residue (SEVERAL)
Thr phosphorylation site {T984}
Ser phosphorylation site {S1000}
Thr phosphorylation site {T1011}
Ser phosphorylation site {S1209}
Ser phosphorylation site {S1263}
PDZ domain
NAME: PDZ domain
SITE: 1350-1429
PDZ domain
NAME: PDZ domain
SITE: 1501-1582
src homology 3 [SH3] domain
SITE: 1593-1661
domain {1722-1905}
HOMOLOGY: guanylate kinase
Database Correlations
OMIM 604090
UniProt Q8TDM6
PFAM correlations
Entrez Gene 9231
Kegg hsa:9231
References
UniProt :accession Q8TDM6