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disks large-associated protein 1; DAP-1; guanylate kinase-associated protein; hGKAP; SAP90/PSD-95-associated protein 1; SAPAP1; PSD-95/SAP90-binding protein 1 (DLGAP1 DAP1 GKAP)
Function:
- part of the postsynaptic scaffold in neuronal cells
- interacts with guanylate kinase-like domain of DLG1, DLG2, DLG3, DLG4 & AIP1
- interacts with the PDZ domain of SHANK1, SHANK2 & SHANK3
- found in a complex with DLG4 & SHANK1, SHANK2 or SHANK3
- found in a complex with DLG4 & BEGAIN
- interacts with DYL2 & LRFN1 (putative)
Structure: belongs to the SAPAP family
Compartment:
- cell membrane, cell junction
- synapse, postsynaptic cell membrane, postsynaptic density
- found in postsynaptic density of neurons (putative)
Alternative splicing: named isoforms=3
Expression: expressed in brain
Interactions
molecular events
General
phosphoprotein
scaffold protein
Properties
SIZE: entity length = 977 aa
MW = 109 kD
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: Tyr phosphorylation site {Y123}
Ser phosphorylation site {S134}
Ser phosphorylation site {S346}
Ser phosphorylation site {S356}
Ser phosphorylation site {S383}
Ser phosphorylation site {S406}
Ser phosphorylation site {S415}
Thr phosphorylation site {T430}
Ser phosphorylation site {S431}
Ser phosphorylation site {S440}
Ser phosphorylation site {S493}
Ser phosphorylation site {S503}
Ser phosphorylation site {S510}
threonine-rich region {622-630}
MOTIF: threonine residue (SEVERAL)
DYL2 interaction {650-661}
DYL2 interaction {672-683}
Ser phosphorylation site {S932}
PDZ recognition motif
NAME: PDZ recognition motif
SITE: 975-977
FOR-BINDING-VIA: PDZ domain
Database Correlations
OMIM 605445
UniProt O14490
Pfam PF03359
Entrez Gene 9229
Kegg hsa:9229
References
- Sheng M.
Molecular organization of the postsynaptic specialization.
Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7058-61. Review.
PMID: 11416187
- UniProt :accession O14490
Component-of
molecular complex