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discoidin, CUB & LCCL domain-containing protein 2 (endothelial & smooth muscle cell-derived neuropilin-like protein; CUB, LCCL & coagulation factor V/VIII-homology domains protein 2; DCBLD2; CLCP1; ESDN)
Structure:
- contains 1 CUB domain
- contains 1 F5/8 type C domain
- contains 1 LCCL domain
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- expressed in testis, heart, skeletal muscle, cultured vascular smooth muscle cells
Pathology:
- increased in lung cancers during the process of tumor progression
General
glycoprotein
membrane protein
Properties
SIZE: MW = 85 kD
entity length = 775 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-66}
CUB domain {72-186}
MOTIF: cysteine residue {C72}
MODIFICATION: cysteine residue {C99}
N-glycosylation site {N95}
cysteine residue {C99}
MODIFICATION: cysteine residue {C72}
cysteine residue {C126}
MODIFICATION: cysteine residue {C148}
cysteine residue {C148}
MODIFICATION: cysteine residue {C126}
N-glycosylation site {N155}
LCCL domain {187-285}
MOTIF: cysteine residue {C215}
MODIFICATION: cysteine residue {C237}
cysteine residue {C237}
MODIFICATION: cysteine residue {C215}
N-glycosylation site {N272}
coagulation factors 5/8 type C domain (FA58C) {292-449}
MOTIF: cysteine residue {C292}
MODIFICATION: cysteine residue {C449}
cysteine residue {C449}
MODIFICATION: cysteine residue {C292}
proline-rich region
SITE: 463-466
MOTIF: proline residue (SEVERAL)
N-glycosylation site {N474}
N-glycosylation site {N516}
N-glycosylation site {N522}
transmembrane domain {529-549}
Database Correlations
OMIM 608698
UniProt Q96PD2
PFAM correlations
References
UniProt :accession Q96PD2