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dipivefrin ophthalmic (Propine)
Tradename: Propine.
Indications:
1) open-angle glaucoma
2) secondary glaucoma
3) ocular hypertension
4) low-tension glaucoma
5) pseudoexfoliative glaucoma
Contraindications: angle-closure glaucoma
Dosage: 1 drop OU BID. 0.1%
Adverse effects:
1) not common (1-10%)
- headache, burning, stinging, ocular congestion, photophobia, mydriasis, blurred vision, ocular pain, conjunctival follicles, blepharoconjunctivitis, macular edema in up to 30% of patients with aphakia
2) uncommon (< 1%)
- arrhythmias, hypertension
Mechanism of action:
1) prodrug of epinephrine
2) stimulates alpha &/or beta adrenergic receptors
3) increases flow of aqueous humor
4) 4-11 times as potent as epinephrine in decreasing intraocular pressure
5) 5-12 times as potent as epinephrine in producing mydriasis
General
dipivefrin (Propine)
ophthalmic agent (eyedrops)
Properties
MISC-INFO: pregnancy-category B
safety in lactation ?
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998