diphthamide biosynthesis protein 1 (DPH1 homolog, HsDph1, diphthamide biosynthesis protein 2 homolog-like 1, DPH2-like 1, diphthamide biosynthesis protein 2-like, DPH-like 1, ovarian cancer-associated gene 1 protein, DPH1, DPH2L, DPH2L1, OVCA1)

Function: - required for the first step in the synthesis of diphthamide - when overexpressed, suppresses colony formation ability & growth rate of ovarian cancer cells - tumor suppressor in lung & breast cancers (putative) - role in embryonic growth, organogenesis & postnatal survival (putative) - interacts with DPH2 (putative) - interacts with RBM8A Structure: belongs to the DPH1/DPH2 family, DPH1 subfamily Compartment: - nucleus, cytoplasm - punctate, primarily perinuclear localization Alternative splicing: named isoforms=3 Expression: - expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, mammary gland, colon, small intestine, testis & ovary Pathology: - diminished expression in primary breast & ovarian tumors Note: uncertain whether Met-1 or Met-6 is the initiator

General

anti-oncoprotein (tumor suppressor protein) nuclear protein

Properties

SIZE: entity length = 443 aa MW = 49 kD COMPARTMENT: cell nucleus

Database Correlations

OMIM 603527 UniProt Q9BZG8 Pfam PF01866

References

UniProt :accession Q9BZG8