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dipeptidyl peptidase 2; dipeptidyl aminopeptidase II; dipeptidyl peptidase 7; dipeptidyl peptidase II; DPP II; quiescent cell proline dipeptidase (DPP7, DPP2, QPP)
Function:
- role in degradation of some oligopeptides
- release of an N-terminal dipeptide, Xaa-Yaa-|-, preferentially when Yaa is Ala or Pro
- substrates are oligopeptides, preferentially tripeptides
- pH dependence:
- optimum pH is 5.5.
- low activity at pH 7
- inactive at pH 8
Structure:
- N-glycosylated
- homodimer
- belongs to the peptidase S28 family
Compartment:
- lysosome, cytoplasmic vesicle, secreted
Expression:
- detected in seminal plasma (at protein level)
General
aminopeptidase
dipeptidyl peptidase (DPP)
glycoprotein
Properties
SIZE: entity length = 492 aa
MW = 54 kD
COMPARTMENT: lysosome
cytoplasm
MOTIF: signal sequence {1-21}
N-glycosylation site {N50}
N-glycosylation site {N86}
serine residue {S162}
N-glycosylation site {N315}
N-glycosylation site {N356}
N-glycosylation site {N363}
aspartate residue {D418}
N-glycosylation site {N428}
histidine residue {H443}
Database Correlations
OMIM 610537
UniProt Q9UHL4
Pfam PF05577
Entrez Gene 29952
Kegg hsa:29952
ENZYME 3.4.14.2
References
UniProt :accession Q9UHL4