dimethylarginine dimethylaminohydrolase 1 (NG,NG-dimethylarginine dimethylaminohydrolase 1, dimethylargininase-1, DDAHI, DDAH-1, DDAH1, DDAH)

Function: 1) hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) & N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of nitric oxide synthase (NOS) 2) nitric oxide generation. Cofactor: binds 1 Zn⁺²

General

hydrolase metalloprotein

Properties

SIZE: MW = 31 kD entity length = 284 aa MOTIF: acetylation site SITE: 1-1 EFFECTOR-BOUND: acetyl binding site SITE: 29-29 FOR-BINDING-OF: Substrate binding site SITE: 77-77 FOR-BINDING-OF: Substrate binding site SITE: 78-78 FOR-BINDING-OF: Substrate binding site SITE: 97-97 FOR-BINDING-OF: Substrate binding site SITE: 144-144 FOR-BINDING-OF: Substrate binding site SITE: 267-267 FOR-BINDING-OF: Substrate Zn+2-binding site SITE: 273-273

Database Correlations

OMIM 604743 UniProt O94760 Pfam PF02274 ENZYME 3.5.3.18

References

UniProt :accession O94760