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dihydroxyacetone phosphate acyltransferase; DAP-AT; DHAP-AT; acyl-CoA:dihydroxyacetonephosphateacyltransferase; glycerone-phosphate O-acyltransferase (GNPAT, DAPAT, DHAPAT)
Function:
- membrane lipid metabolism; glycerophospholipid metabolism
- may be part of an heterotrimeric complex composed of DAP-AT, ADAP-S & a modified form of DAP-AT
acyl-CoA + glycerone phosphate = CoA + acyl-glycerone phosphate
Structure:
- the HXXXXD motif is essential for acyltransferase activity & may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (putative)
- belongs to the GPAT/DAPAT family
Compartment:
- peroxisome membrane; matrix side
- exclusively localized to the lumenal side of the peroxisomal membrane (putative)
Pathology:
- defects in GNPAT are the cause of rhizomelic chondrodysplasia punctata, type 2
Laboratory:
- dihydroxyacetone phosphate acyltransferase in fibroblasts
General
acyltransferase
Properties
SIZE: entity length = 680 aa
MW = 77 kD
COMPARTMENT: peroxisome
MOTIF: serine-rich region {3-9}
MOTIF: serine residue (SEVERAL)
HXXXXD {162-167}
active site
microbody-targeting signal {678-680}
Database Correlations
OMIM correlations
MORBIDMAP 602744
UniProt O15228
Pfam PF01553
Entrez Gene 8443
KEGG correlations
ENZYME 2.3.1.42
References
- UniProt :accession O15228
- GeneReviews
http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/GNPAT