differentially expressed in FDCP 6 (DEF-6, IRF4-binding protein, DEF6, IBP)

Function: - PtdInsP3-dependent guanine nucleotide exchange factor - role in activation of Rho GTPases RAC1, RhoA & CDC42 - regulates cell morphology in cooperation with activated RAC1 (putative) - role in Th2 (T helper cells) development &/or activation, via interfering with ZAP-70 signaling (putative) - interacts with ZAP70 - interacts with IRF4, activated RAC1 & F-actin - Tyr-phosphorylated by tyrosine-protein kinase LCK in response to T-cell activation - both the phosphorylated & non-phosphorylated forms bind PtdInsP3 Structure: - contains 1 PH domain, essential for PtdInsP3 binding Compartment: - cytoplasm, cell membrane, nucleus - recruited to the plasma membrane upon binding PtdInsP3 Alternative splicing: named isoforms=1 Expression: - broadly expressed in the immune system - detected in T & B-cells

General

guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS) phosphoprotein

Properties

SIZE: MW = 74 kD entity length = 631 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: Tyr phosphorylation site {Y210} PH domain {216-312} glutamate-rich region {331-497} MOTIF: glutamate residue (SEVERAL)

Database Correlations

UniProt Q9H4E7 Pfam PF00169

References

UniProt :accession Q9H4E7