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diethylpropion (Amfepramone, Frekentine, Moderatan, Dobesin)
DEA-controlled substance: class 4.
Indications:
-> appetite suppressant
Dosage:
1) 25 mg PO before meals
2) 75 mg PO QAM (slow release)
3) 25-75 mg PO QD
Pharmacokinetics:
1) metabolized in liver to largely inactive metabolites
2) metabolites excreted by the kidney
Adverse effects:
1) insomnia
2) agitation
3) nervousness
4) hyperthermia
5) hyperventilation
6) hypertension
7) convulsions
Interferences:
-> may cause false positives in immunoassays for amphetamines in urine
Mechanism of action:
1) CNS stimulants
2) appetite suppressant
Interactions
drug adverse effects (more general classes)
General
adrenergic neuron stimulant
amine
analeptic (CNS stimulant)
aromatic compound
Properties
MISC-INFO: elimination route LIVER
KIDNEY
1/2life 4-6 HOURS
therapeutic-range 0.001-0.01 UG/ML
toxic-range >1 UG/ML
Database Correlations
PUBCHEM correlations
References
- Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,
W.B. Saunders, 1995
- Harrison's Principles of Internal Medicine, 14th ed.
Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 461