Dickkopf-related protein 4; Dickkopf-4; Dkk-4; hDkk-4 (DKK4)

Function: - antagonizes canonical Wnt signaling by inhibiting LRP5 &/or LRP6 - interaction with Wnt & by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5 &/or LRP6 - DKKs play a role in vertebrate development, where they locally inhibit Wnt regulated processes such as anteroposterior axial patterning, limb development, somitogenesis & eye formation - in adults, Dkks are implicated in bone formation - interacts with LRP5 & LRP6 (putative) - can be proteolytically processed by a furin-like protease Structure: - appears to be not glycosylated - the C-terminal cysteine-rich domain mediates interaction with LRP5 & LRP6 (putative) - belongs to the dickkopf family Compartment: secreted Expression: - expressed in cerebellum, T-cells, esophagus & lung Pathology: - Dkks are implicated in bone disease, cancer & Alzheimer disease

Properties

SIZE: entity length = 224 aa MW = 25 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-18} DKK-type Cys-1 {41-90} DKK-type Cys-2 {145-218} MOTIF: cysteine residue {C145} MODIFICATION: cysteine residue {C157} cysteine residue {C151} MODIFICATION: cysteine residue {C166} cysteine residue {C156} MODIFICATION: cysteine residue {C194} cysteine residue {C157} MODIFICATION: cysteine residue {C145} cysteine residue {C166} MODIFICATION: cysteine residue {C151} cysteine residue {C176} MODIFICATION: cysteine residue {C202} cysteine residue {C194} MODIFICATION: cysteine residue {C156} cysteine residue {C196} MODIFICATION: cysteine residue {C218} cysteine residue {C202} MODIFICATION: cysteine residue {C176} cysteine residue {C218} MODIFICATION: cysteine residue {C196}

Database Correlations

OMIM 605417 UniProt Q9UBT3 PFAM correlations Entrez Gene 27121 Kegg hsa:27121

References

UniProt :accession Q9UBT3