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Dickkopf-related protein 2; Dickkopf-2; Dkk-2; hDkk-2 (DKK2)
Function:
- antagonizes canonical Wnt signaling by inhibiting LRP5 &/or LRP6
- interaction with Wnt & by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5 &/or LRP6
- DKKs play a role in vertebrate development, where they locally inhibit Wnt regulated processes such as anteroposterior axial patterning, limb development, somitogenesis & eye formation
- in the adult, Dkks are implicated in bone formation
- may be proteolytically processed by a furin-like protease
- interacts with LRP5 & LRP6 (putative)
Structure:
- the C-terminal cysteine-rich domain mediates interaction with LRP5 & LRP6 (putative)
- belongs to the dickkopf family
Compartment: secreted
Expression:
- expressed in heart, brain, skeletal muscle & lung
Pathology:
- Dkks are implicated in bone disease, cancer & Alzheimer disease
General
Dickkopf homolog
Properties
SIZE: entity length = 259 aa
MW = 28 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-33}
N-glycosylation site {N52}
DKK-type Cys-1 {78-127}
DKK-type Cys-2 {183-256}
MOTIF: cysteine residue {C183}
MODIFICATION: cysteine residue {C195}
cysteine residue {C189}
MODIFICATION: cysteine residue {C204}
cysteine residue {C194}
MODIFICATION: cysteine residue {C231}
cysteine residue {C195}
MODIFICATION: cysteine residue {C183}
cysteine residue {C204}
MODIFICATION: cysteine residue {C189}
cysteine residue {C214}
MODIFICATION: cysteine residue {C239}
cysteine residue {C231}
MODIFICATION: cysteine residue {C194}
cysteine residue {C233}
MODIFICATION: cysteine residue {C256}
cysteine residue {C239}
MODIFICATION: cysteine residue {C214}
cysteine residue {C256}
MODIFICATION: cysteine residue {C233}
Database Correlations
OMIM 605415
UniProt Q9UBU2
Pfam PF04706
Entrez Gene 27123
Kegg hsa:27123
References
UniProt :accession Q9UBU2