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Dickkopf homolog
Function:
- secreted inhibitor of Wnt signaling
- DKKs play a role in vertebrate development, where they locally inhibit Wnt regulated processes such as anteroposterior axial patterning, limb development, somitogenesis & eye formation
- inhibits Wnt signaling by binding to the LRP5/LRP6 component of the Wnt receptor complex
- in adults, Dkks are implicated in bone formation
Compartment: secreted
Pathology:
- Dkks are implicated in bone disease, cancer & Alzheimer disease
Specific
Dickkopf-related protein 1; Dickkopf-1; Dkk-1; hDkk-1; SK (DKK1)
Dickkopf-related protein 2; Dickkopf-2; Dkk-2; hDkk-2 (DKK2)
Dickkopf-related protein 3; Dickkopf-3; Dkk-3; hDkk-3 (DKK3, REIC, UNQ258/PRO295)
Dickkopf-related protein 4; Dickkopf-4; Dkk-4; hDkk-4 (DKK4)
General
secreted protein
Properties
COMPARTMENT: extracellular compartment
References
- Kawano Y & Kypta R.
Secreted antagonists of the Wnt signalling pathway.
J Cell Sci 116:2627-2634, 2003
PMID: 12775774