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dichlorodiphenyltrichloroethane; chlorophenothane; clofenotane (DDT)
Banned insecticide.
Metabolized to dichlorodiphenyldichloroethylene (DDE)
Adverse effects:
- higher serum levels of metabolite DDE associated with increased risk & increased severity of Alzheimer's disease [2]
- HR=3 with highest tertile of serum levels of DDE [2]
- probably carcinogenic to humans [3]
- increased risk for non-Hodgkin's lymphoma, testicular cancer, & liver cancers [3]
- prenatal exposure linked to increased risk of autism in offspring [4]
General
aromatic compound
pesticide
Database Correlations
PUBCHEM cid=3036
References
- PubChem: 3036
- Richardson JR et al
Elevated Serum Pesticide Levels and Risk for Alzheimer Disease.
JAMA Neurol. Published online January 27, 2014
PMID: 24473795
http://archneur.jamanetwork.com/article.aspx?articleid=1816015
- DeKosky ST and Gandy S
Environmental Exposures and the Risk for Alzheimer Disease.
Can We Identify the Smoking Guns?
JAMA Neurol. Published online January 27, 2014
PMID: 24473699
http://archneur.jamanetwork.com/article.aspx?articleid=1816013
- World Health Organization (WHO). Press Release. June 2015
International Agency for Research on Cancer.
IARC Monographs evaluate DDT, lindane, and 2,4-D
http://www.iarc.fr/en/media-centre/pr/2015/pdfs/pr236_E.pdf
- Brown AS, Cheslack-Postava K, Rantakokko P et al
Association of Maternal Insecticide Levels With Autism in
Offspring From a National Birth Cohort.
Am J Psychiatry. Aug 16, 2018
PMID: 30111184
https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2018.17101129
- American Psychiatric Association. Aug 16, 2018
Study Links Mothers' Pesticide Levels with Autism in Children.
https://www.psychiatry.org/newsroom/news-releases/study-links-mothers-pesticide-levels-with-autism-in-children