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dichlorodiphenyldichloroethylene (DDE)
Metabolite of pesticide dichlorodiphenyltrichloroethane (DDT)
Pathology:
- higher serum levels of DDE associated with increased risk & increased severity of Alzheimer's disease [2]
- HR=3 with highest tertile of serum levels [2]
- prenatal exposure to pesticide DDT may increase risk for autism [3]
Laboratory:
- o,p'- DDE in specimen
General
aromatic compound
pesticide
Database Correlations
PUBCHEM cid=3035
References
- PubChem: 3035
- Richardson JR et al
Elevated Serum Pesticide Levels and Risk for Alzheimer Disease.
JAMA Neurol. Published online January 27, 2014
PMID: 24473795
http://archneur.jamanetwork.com/article.aspx?articleid=1816015
- DeKosky ST and Gandy S
Environmental Exposures and the Risk for Alzheimer Disease.
Can We Identify the Smoking Guns?
JAMA Neurol. Published online January 27, 2014
PMID: 24473699
http://archneur.jamanetwork.com/article.aspx?articleid=1816013
- Brooks M
First Biomarker Evidence Autism Is Linked to DDT.
Medscape - Aug 16, 2018.
https://www.medscape.com/viewarticle/900776