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protein diaphanous homolog 3; diaphanous-related formin-3; DRF3 (DIAPH3 DIAP3)
Function:
- binds to GTP-bound form of Rho & to profilin
- recruits profilin to the membrane (Rho-dependent), where it promotes actin polymerization
- required for cytokinesis, stress fiber formation, & transcriptional activation of serum response factor
- DFR proteins couple Rho & Src tyrosine kinase during signaling & the regulation of actin dynamics
- DRFs are regulated by intramolecular GBD-DAD binding where Rho-GTP activates the DRFs by disrupting the GBD-DAD interaction
Structure:
- belongs to the formin homology family, diaphanous subfamily
- contains 1 DAD (diaphanous autoregulatory) domain
- contains 1 FH1 (formin homology 1) domain
- contains 1 FH2 (formin homology 2) domain
- contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain
Alternative splicing: named isoforms=7
General
formin homology family protein
Properties
SIZE: entity length = 1193 aa
MW = 137 kD
COMPARTMENT: cytoplasm
MOTIF: GBD/FH3 {114-476}
coiled coil {497-554}
proline-rich region
SITE: 561-636
MOTIF: proline residue (SEVERAL)
FH1 {561-631}
FH2 {636-1034}
coiled coil {1013-1056}
DAD {1057-1087}
Database Correlations
UniProt Q9NSV4
PFAM correlations
Entrez Gene 81624
Kegg hsa:81624
References
UniProt :accession Q9NSV4