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formin-2; diaphanous-related formin 2 (FMN2)
Function:
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure:
- belongs to the formin homology family, Cappuccino subfamily
- contains 1 FH1 (formin homology 1) domain
- contains 1 FH2 (formin homology 2) domain
Expression:
- expressed almost exclusively in the developing & mature central nervous system
General
formin homology family protein
phosphoprotein
Properties
SIZE: entity length = 1722 aa
MW = 180 kD
COMPARTMENT: cytoplasm
MOTIF: coiled coil {193-231}
MOTIF: glutamine-rich region {200-227}
MOTIF: glutamine residue (SEVERAL)
Ser phosphorylation site {S361}
Ser phosphorylation site {S396}
Ser phosphorylation site {S400}
Ser phosphorylation site {S404}
Ser phosphorylation site {S516}
coiled coil {670-706}
Thr phosphorylation site {T746}
FH1 {758-1268}
MOTIF: proline-rich region
SITE: 758-1268
MOTIF: proline residue (SEVERAL)
FH2 {1283-1698}
MOTIF: coiled coil {1567-1597}
coiled coil {1677-1699}
Database Correlations
OMIM 606373
UniProt Q9NZ56
PFAM correlations
Entrez Gene 56776
Kegg hsa:56776
References
UniProt :accession Q9NZ56