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diacylglycerol kinase zeta; DAG kinase zeta; diglyceride kinase zeta; DGK-zeta (DGKZ, DAGK6)
Function:
- strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among long chain diacylglycerols
- isoform 2 but not isoform 1 regulates RASGRP1 activity
- phosphorylation of the MARCKS homology domain by PKC reduces nuclear accumulation of DGK-zeta
- interacts with the PDZ domain of the syntrophin SNTG1 & that of SNX27
- isoform 2 forms a signaling complex with RASGRP1 & HRAS
ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate
Structure:
- belongs to the eukaryotic diacylglycerol kinase family
- contains 2 ANK repeats
- contains 1 DAGKc domain
- contains 2 phorbol-ester/DAG-type Zn+2 fingers
Compartment: cytoplasm, nucleus, cell membrane
Alternative splicing: named isoforms=2
Expression:
- highest levels in brain
- high levels in skeletal muscle, heart, & pancreas
- isoform 1 is predominantly expressed in muscle
General
ankyrin repeat domain protein (ANKRD)
diacylglycerol kinase
phosphoprotein
zinc finger protein
Properties
SIZE: entity length = 1117 aa
MW = 124 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: proline-rich region
SITE: 256-261
MOTIF: proline residue (SEVERAL)
Zinc finger
NAME: Zinc finger
SITE: 287-341
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 361-419
EFFECTOR-BOUND: Zn+2
MARCKS homology {448-462}
MOTIF: lysine-rich region {448-451}
MOTIF: lysine residue (SEVERAL)
Mediates interaction with RASGRP1 {467-605}
DAGKc {480-614}
MOTIF: proline-rich region
SITE: 560-563
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S686}
ankyrin repeat
NAME: ankyrin repeat
SITE: 1011-1041
ankyrin repeat
NAME: ankyrin repeat
SITE: 1046-1075
Database Correlations
OMIM 601441
UniProt Q13574
PFAM correlations
Entrez Gene 8525
Kegg hsa:8525
ENZYME 2.7.1.107
References
UniProt :accession Q13574