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destrin; actin-depolymerizing factor; ADF (DSTN ACTDP DSN)
Function:
- destrin has weak F-actin severing activity
- binds to actin monomers
- appears to 'nibble' monomer from F-actin leaving free barbed end.
- action similar to cofilin
- phospholipid binding may reduce affinity for G-actin [1]
- pH-independent action
Structure:
- belongs to the actin-binding proteins ADF family
- contains 1 ADF-H domain
Expression: widely distributed in various tissues
General
cytoskeletal protein
phosphoprotein
Properties
SIZE: entity length = 165 aa
MW = 19 kD
COMPARTMENT: cytoplasm
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S3}
ADF-H {4-153}
MOTIF: nuclear translocation signal {30-34}
Database Correlations
OMIM 609114
UniProt P60981
Pfam PF00241
Entrez Gene 11034
Kegg hsa:11034
References
- Stossel TP.
On the crawling of animal cells.
Science. 1993 May 21;260(5111):1086-94. Review.
PMID: 8493552
- UniProt :accession P60981