dermokine (epidermis-specific secreted protein SK30/SK89, DMKN)

Function: - may act as a soluble regulator of keratinocyte differentiation (putative) Structure: - O-glycosylated - homooligomer, seems to be able to homodimerize & homotrimerize - belongs to the dermokine family Compartment: secreted Alternative splicing: named isoforms=15 Expression: - expressed in epidermis; in the spinous & granular layers - expressed in placenta - found in the epithelia of the small intestine, macrophages of the lung & endothelial cells of the lung - isoform 15 is expressed in epidermis & placenta & - isoform 1 is expressed in epidermis

General

paracrine hormone secreted protein

Properties

SIZE: entity length = 476 aa MW = 47 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-21} glycine-rich region {17-344}

References

UniProt :accession Q6E0U4