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dermcidin (preproteolysin, [Contains: Survival-promoting peptide; DCD-1], DCD, AIDD, DSEP)
Function:
1) DCD-1 displays antimicrobial activity, limiting skin infection by potential pathogens in the first few hours after bacterial colonization
2) highly effective against E. coli, E. faecalis, S. aureus & C. albicans.
3) optimal pH & salt concentration resemble the conditions in sweat
4) survival-promoting peptide promotes survival of neurons & displays phosphatase activity
5) may bind IgG
Cofactor: Mn+2 required for survival-promoting peptide
Compartment:
- secreted into the sweat at a concentration of 1-10 ug/mL
Expression:
- specifically & constitutively expressed in eccrine sweat glands
General
secreted protein
Properties
SIZE: MW = 11 kD
entity length = 110 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-19}
Database Correlations
OMIM 606634
UniProt P81605
References
- UniProt :accession P81605
- Protein Spotlight
Smart sweat - Issue 18 of January 2002
http://www.expasy.org/spotlight/back_issues/sptlt018.shtml