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dermatopontin; tyrosine-rich acidic matrix protein; TRAMP (DPT)
Function:
- seems to mediate adhesion by cell surface integrin binding
- may serve as a communication link between the dermal fibroblast cell surface & its extracellular matrix environment
- enhances TGFB1 activity
- inhibits cell proliferation
- accelerates collagen fibril formation, & stabilizes collagen fibrils against low-temperature dissociation (putative)
- sulfated on Tyr (putative)
- interacts with TGFB1, DCN & collagen (putative)
Structure:
- belongs to the dermatopontin family
Compartment:
- secreted, extracellular space, extracellular matrix (putative)
Expression:
- expressed in fibroblasts, heart, skeletal muscle, brain & pancreas
- expressed at an intermediate level in lung & kidney
- expressed at a low level in liver & placenta
- expressed at a lower level in fibroblasts from hypertrophic scar lesional skin & in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts
- induced by TGFB1, repressed by IL4/interleukin-4
General
secreted protein
Properties
SIZE: entity length = 201 aa
MW = 24 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-18}
2 X 53-55 AA tandem repeats {26-186}
MOTIF: consensus repeat {26-79}
cysteine residue {C50}
MODIFICATION: cysteine residue {C77}
consensus repeat {70-186}
consensus repeat {70-75}
cysteine residue {C77}
MODIFICATION: cysteine residue {C50}
consensus repeat {80-135}
cysteine residue {C90}
MODIFICATION: cysteine residue {C132}
cysteine residue {C106}
MODIFICATION: cysteine residue {C133}
consensus repeat {125-130}
cysteine residue {C132}
MODIFICATION: cysteine residue {C90}
cysteine residue {C133}
MODIFICATION: cysteine residue {C106}
cysteine residue {C139}
MODIFICATION: cysteine residue {C196}
cysteine residue {C143}
MODIFICATION: cysteine residue {C189}
consensus repeat {181-186}
cysteine residue {C189}
MODIFICATION: cysteine residue {C143}
cysteine residue {C196}
MODIFICATION: cysteine residue {C139}
Database Correlations
OMIM 125597
UniProt Q07507
Entrez Gene 1805
Kegg hsa:1805
References
- UniProt :accession Q07507
- OMIM :accession 125597