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dishevelled, egl-10, pleckstrin (DEP) domain
A globular domain of about 80 amino acid residues found > 50 proteins involved in G protein signaling. Its name is derived from 3 proteins (Dishevelled, Egl-10, & Pleckstrin) in which it was initially identified. The DEP domain is thought to play a role in targeting to specific subcellular membranes.
The DEP domain consists of a 3-helix bundle, a beta-hairpin 'arm' consisting of 2 beta- strands & 2 short beta-strands in the C-terminal region.
General
domain
peptide motif
References
- Ponting CP, Bork P.
Pleckstrin's repeat performance: a novel domain in G-protein
signaling?
Trends Biochem Sci. 1996 Jul;21(7):245-6.
PMID: 8755244
- prosite :accession PS50186