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deoxyribonuclease-2-beta; Dnase II-like acid Dnase; Dnase2-like acid Dnase; deoxyribonuclease II beta; Dnase II beta; endonuclease DLAD (DNASE2B, DLAD)
Function:
- hydrolyzes DNA under acidic conditions
- does not require divalent cations for activity
- participates in degradation of nuclear DNA during lens cell differentiation
- endonucleolytic cleavage to nucleoside 3'-phosphates & 3'-phosphooligonucleotide end-products
Structure: belongs to the Dnase II family
Compartment: lysosome (probable)
Alternative splicing: named isoforms=2
Expression:
- highly expressed in the eye lens & in salivary gland
- detected at lower levels in lung, prostate & lymph node
- isoform 2 is lung specific
General
endodeoxyribonuclease
glycoprotein
Properties
SIZE: entity length = 361 aa
MW = 42 kD
COMPARTMENT: lysosome
MOTIF: signal sequence {1-27}
N-glycosylation site {N81}
N-glycosylation site {N103}
N-glycosylation site {N119}
N-glycosylation site {N278}
Database Correlations
OMIM 608057
UniProt Q8WZ79
Pfam PF03265
Entrez Gene 58511
Kegg hsa:58511
ENZYME 3.1.22.1
References
UniProt :accession Q8WZ79